Chapter title |
Nasopharyngeal Infection of Mice with Streptococcus pyogenes and In Vivo Detection of Superantigen Activity
|
---|---|
Chapter number | 8 |
Book title |
Superantigens
|
Published in |
Methods in molecular biology, December 2015
|
DOI | 10.1007/978-1-4939-3344-0_8 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3342-6, 978-1-4939-3344-0
|
Authors |
Joseph J. Zeppa, Adrienne T. Wakabayashi, Katherine J. Kasper, Stacey X. Xu, S. M. Mansour Haeryfar, John K. McCormick |
Editors |
Amanda J. Brosnahan |
Abstract |
Streptococcus pyogenes is a globally prominent human-specific pathogen that is responsible for an enormous burden of infectious disease. Despite intensive experimental efforts to understand the molecular correlates that contribute to invasive infections, there has been less focus on S. pyogenes carriage and local infection of the nasopharynx. This chapter describes an acute nasopharyngeal infection model in mice that is utilized in our laboratory to study the role of superantigen toxins in the biology of S. pyogenes. We also describe a method to detect superantigen-specific T cell activation in vivo. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 20% |
Student > Ph. D. Student | 4 | 20% |
Student > Bachelor | 3 | 15% |
Professor | 2 | 10% |
Student > Master | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 7 | 35% |
Agricultural and Biological Sciences | 3 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 15% |
Medicine and Dentistry | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 15% |