Chapter title |
Lipopolysaccharide-Induced Toxic Shock Syndrome in Rabbits
|
---|---|
Chapter number | 5 |
Book title |
Superantigens
|
Published in |
Methods in molecular biology, December 2015
|
DOI | 10.1007/978-1-4939-3344-0_5 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3342-6, 978-1-4939-3344-0
|
Authors |
Christopher S. Stach, Patrick M. Schlievert |
Editors |
Amanda J. Brosnahan |
Abstract |
Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of which have yet to be fully characterized. Testing the capacity of superantigens to potentiate LPS sensitivity is essential to characterize the role of these proteins in disease development. Here we describe how to perform studies of the enhancement of LPS-induced toxic shock syndrome in rabbits. This protocol also provides information on a second important activity of superantigens: the production of fever. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 56% |
Student > Bachelor | 3 | 33% |
Unknown | 1 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 1 | 11% |
Environmental Science | 1 | 11% |
Psychology | 1 | 11% |
Immunology and Microbiology | 1 | 11% |
Unknown | 5 | 56% |