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Superantigens

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Cover of 'Superantigens'

Table of Contents

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    Book Overview
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    Chapter 1 Animal Models Used to Study Superantigen-Mediated Diseases.
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    Chapter 2 Identification, Purification, and Characterization of Staphylococcal Superantigens
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    Chapter 3 Strain Discrimination of Staphylococcus aureus Using Superantigen Profiles
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    Chapter 4 Crystallization and Structure Determination of Superantigens and Immune Receptor Complexes
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    Chapter 5 Lipopolysaccharide-Induced Toxic Shock Syndrome in Rabbits
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    Chapter 6 Aortic Valve Damage for the Study of Left-Sided, Native Valve Infective Endocarditis in Rabbits
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    Chapter 7 Rabbit Model for Superantigen-Mediated Lethal Pulmonary Disease
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    Chapter 8 Nasopharyngeal Infection of Mice with Streptococcus pyogenes and In Vivo Detection of Superantigen Activity
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    Chapter 9 Mini-Osmotic Pump Infusion Model to Investigate the Systemic Effects of Chronic Continuous Exposure to Staphylococcal Superantigen in Mice
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    Chapter 10 A Sublethal Swine Model for Defining In Vivo Superantigen-Induced Responses Following Exposure to Staphylococcal Enterotoxin B.
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    Chapter 11 Monkey Feeding Assay for Testing Emetic Activity of Staphylococcal Enterotoxin
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    Chapter 12 Use of an Ex Vivo Porcine Mucosal Model to Study Superantigen Penetration
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    Chapter 13 Protocol for Examining Human Vaginal Epithelial Cell Signaling in Response to Staphylococcal Superantigens.
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    Chapter 14 Organ Culture as a Model System for Studies on Enterotoxin Interactions with the Intestinal Epithelium
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    Chapter 15 Quantification of a Selective Expansion of T Cell Receptor Vβ by Superantigen Using Real-Time PCR
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    Chapter 16 Induction of Human Regulatory T Cells with Bacterial Superantigens
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    Chapter 17 Construction of Recombinant Single Chain Variable Fragment (ScFv) Antibody Against Superantigen for Immunodetection Using Antibody Phage Display Technology.
Attention for Chapter 5: Lipopolysaccharide-Induced Toxic Shock Syndrome in Rabbits
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Chapter title
Lipopolysaccharide-Induced Toxic Shock Syndrome in Rabbits
Chapter number 5
Book title
Superantigens
Published in
Methods in molecular biology, December 2015
DOI 10.1007/978-1-4939-3344-0_5
Pubmed ID
Book ISBNs
978-1-4939-3342-6, 978-1-4939-3344-0
Authors

Christopher S. Stach, Patrick M. Schlievert

Editors

Amanda J. Brosnahan

Abstract

Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of which have yet to be fully characterized. Testing the capacity of superantigens to potentiate LPS sensitivity is essential to characterize the role of these proteins in disease development. Here we describe how to perform studies of the enhancement of LPS-induced toxic shock syndrome in rabbits. This protocol also provides information on a second important activity of superantigens: the production of fever.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 56%
Student > Bachelor 3 33%
Unknown 1 11%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 1 11%
Environmental Science 1 11%
Psychology 1 11%
Immunology and Microbiology 1 11%
Unknown 5 56%