| Chapter title |
Mini-Osmotic Pump Infusion Model to Investigate the Systemic Effects of Chronic Continuous Exposure to Staphylococcal Superantigen in Mice
|
|---|---|
| Chapter number | 9 |
| Book title |
Superantigens
|
| Published in |
Methods in molecular biology, December 2015
|
| DOI | 10.1007/978-1-4939-3344-0_9 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3342-6, 978-1-4939-3344-0
|
| Authors |
Ashton L. Krogman, Vaidehi Chowdhary, Govindarajan Rajagopalan D.V.M., Ph.D., Govindarajan Rajagopalan |
| Editors |
Amanda J. Brosnahan |
| Abstract |
Staphylococcus aureus can exist as a colonizer or can cause a spectrum of diseases. S. aureus elaborates several exotoxins and the superantigens are one among them. Staphylococcal superantigens (SSAg) cause robust activation of the immune system and acute exposure to significant amounts of SSAg can be potentially lethal. However, chronic exposure to SSAg is also possible. Administering SSAg using mini-osmotic pumps may mimic chronic recurrent exposure to SSAg. This is a relatively simple and safe way to administer purified SSAg or any other toxin/agent. In this chapter, we describe the mini-osmotic pump-mediated delivery of SSAg. |
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|---|---|---|
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Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 20% |
| Student > Doctoral Student | 1 | 20% |
| Student > Master | 1 | 20% |
| Unknown | 2 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Psychology | 1 | 20% |
| Neuroscience | 1 | 20% |
| Unknown | 1 | 20% |