| Chapter title |
A Sublethal Swine Model for Defining In Vivo Superantigen-Induced Responses Following Exposure to Staphylococcal Enterotoxin B.
|
|---|---|
| Chapter number | 10 |
| Book title |
Superantigens
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3344-0_10 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3342-6, 978-1-4939-3344-0
|
| Authors |
Bost, Kenneth L, Piller, Kenneth J, Odle, Jack, Stahl, Chad H, Kenneth L. Bost, Kenneth J. Piller, Jack Odle, Chad H. Stahl |
| Editors |
Amanda J. Brosnahan |
| Abstract |
In vivo responses to bacterially derived superantigen-like toxins have been difficult to define due to the inherent limitations with rodent models and the relevance that the results obtained from such models may, or may not, have for human pathophysiology. Further the use of challenge doses of superantigen toxins that are lethal or supra-lethal complicates analogies to human exposures which are rarely fatal. Here, we utilize the superantigen, staphylococcal enterotoxin B, at doses that are sublethal in a swine model of toxin-induced incapacitation. Relevant dosing using an animal species for which this toxin is a true superantigen distinguishes this model. |
X Demographics
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Mendeley readers
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| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
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| Researcher | 1 | 33% |
| Unknown | 2 | 67% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 33% |
| Unknown | 2 | 67% |