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Mendeley readers
| Chapter title |
Chemical Library Screens to Identify Pharmacological Modulators of Necroptosis
|
|---|---|
| Chapter number | 3 |
| Book title |
Programmed Necrosis
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-8754-2_3 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-8753-5, 978-1-4939-8754-2
|
| Authors |
Danish Saleh, Alexei Degterev |
| Abstract |
Necroptosis is mediated by the formation of the detergent-insoluble necrosome complex between Ser/Thr kinases RIPK1 and RIPK3, which mediates RIPK3-dependent phosphorylation and activation of the critical necroptosis effector MLKL. Small molecule screens have been instrumental in the development of new chemical probes for this pathway. In this chapter, we describe several cellular assays that are readily amendable for the identification of new modulators of necroptosis as well as secondary assays to facilitate initial characterization of the mode of activity of small molecule hits. |
Mendeley readers
The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 1 | 33% |
| Student > Doctoral Student | 1 | 33% |
| Student > Master | 1 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 33% |
| Chemistry | 1 | 33% |
| Medicine and Dentistry | 1 | 33% |