Chapter title |
HIV Broadly Neutralizing Antibodies: VRC01 and Beyond
|
---|---|
Chapter number | 3 |
Book title |
HIV Vaccines and Cure
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-13-0484-2_3 |
Pubmed ID | |
Book ISBNs |
978-9-81-130483-5, 978-9-81-130484-2
|
Authors |
Xueling Wu, Wu, Xueling |
Abstract |
Developing an effective prophylaxis HIV-1 vaccine is likely to require the elicitation of broadly neutralizing antibodies (bnAbs). As the HIV-1 envelope (Env) glycoprotein - the sole target of bnAbs - has evolved multiple mechanisms to evade antibody neutralization, the processes for bnAb generation are highly selective and time-consuming. Benefiting from antibody isolation technologies of single B cell culturing and direct single B cell sorting and cloning, a new generation of monoclonal bnAbs has been isolated since 2009, exhibiting remarkable breadths and potencies, thus breaking through a nearly 20-year-long limit of four monoclonal bnAbs with moderate breadth and potency. The discovery of a long list of monoclonal bnAbs has provided in-depth understanding of the sites of vulnerability on the HIV-1 Env and the complexity of human B cell immunology to generate such responses, thus presenting both guidance and challenges to move the Env immunogen design effort forward. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 16% |
Student > Ph. D. Student | 3 | 16% |
Professor | 1 | 5% |
Student > Master | 1 | 5% |
Researcher | 1 | 5% |
Other | 2 | 11% |
Unknown | 8 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 4 | 21% |
Biochemistry, Genetics and Molecular Biology | 3 | 16% |
Agricultural and Biological Sciences | 1 | 5% |
Engineering | 1 | 5% |
Unknown | 10 | 53% |