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HIV Vaccines and Cure

Overview of attention for book
Attention for Chapter 5: Monkey Models and HIV Vaccine Research
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Chapter title
Monkey Models and HIV Vaccine Research
Chapter number 5
Book title
HIV Vaccines and Cure
Published in
Advances in experimental medicine and biology, January 2018
DOI 10.1007/978-981-13-0484-2_5
Pubmed ID
Book ISBNs
978-9-81-130483-5, 978-9-81-130484-2
Authors

Zhiwei Chen, Chen, Zhiwei

Abstract

Since the discovery of acquired immunodeficiency syndrome (AIDS) in 1981, it has been extremely difficult to develop an effective vaccine or a therapeutic cure despite over 36 years of global efforts. One of the major reasons is due to the lack of an immune-competent animal model that supports live human immunodeficiency virus (HIV) infection and disease progression such that vaccine-induced correlates of protection and efficacy can be determined clearly before human trials. Nevertheless, rhesus macaques infected with simian immunodeficiency virus (SIV) and chimeric simian human immunodeficiency virus (SHIV) have served as invaluable models not only for understanding AIDS pathogenesis but also for studying HIV vaccine and cure. In this chapter, therefore, we summarize major scientific evidence generated in these models since the beginning of the AIDS pandemic. Hopefully, the accumulated knowledge and lessons contributed by thousands of scientists will be useful in promoting the search of an ultimate solution to end HIV/AIDS.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 18%
Student > Ph. D. Student 1 9%
Student > Bachelor 1 9%
Researcher 1 9%
Student > Postgraduate 1 9%
Other 0 0%
Unknown 5 45%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 18%
Mathematics 1 9%
Immunology and Microbiology 1 9%
Social Sciences 1 9%
Medicine and Dentistry 1 9%
Other 0 0%
Unknown 5 45%