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HIV Vaccines and Cure

Overview of attention for book
Attention for Chapter 9: Cellular Determinants of HIV Persistence on Antiretroviral Therapy
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  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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Chapter title
Cellular Determinants of HIV Persistence on Antiretroviral Therapy
Chapter number 9
Book title
HIV Vaccines and Cure
Published in
Advances in experimental medicine and biology, January 2018
DOI 10.1007/978-981-13-0484-2_9
Pubmed ID
Book ISBNs
978-9-81-130483-5, 978-9-81-130484-2
Authors

Anastassia Mikhailova, Jose Carlos Valle-Casuso, Asier Sáez-Cirión, Mikhailova, Anastassia, Valle-Casuso, Jose Carlos, Sáez-Cirión, Asier

Abstract

The era of antiretroviral therapy has made HIV-1 infection a manageable chronic disease for those with access to treatment. Despite treatment, virus persists in tissue reservoirs seeded with long-lived infected cells that are resistant to cell death and immune recognition. Which cells contribute to this reservoir and which factors determine their persistence are central questions that need to be answered to achieve viral eradication. In this chapter, we describe how cell susceptibility to infection, resistance to cell death, and immune-mediated killing as well as natural cell life span and turnover potential are central components that allow persistence of different lymphoid and myeloid cell subsets that were recently identified as key players in harboring latent and actively replicating virus. The relative contribution of these subsets to persistence of viral reservoir is described, and the open questions are highlighted.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 26%
Student > Ph. D. Student 4 21%
Professor 2 11%
Student > Master 1 5%
Student > Doctoral Student 1 5%
Other 0 0%
Unknown 6 32%
Readers by discipline Count As %
Immunology and Microbiology 5 26%
Biochemistry, Genetics and Molecular Biology 2 11%
Medicine and Dentistry 2 11%
Psychology 1 5%
Agricultural and Biological Sciences 1 5%
Other 0 0%
Unknown 8 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2018.
All research outputs
#13,622,705
of 23,096,849 outputs
Outputs from Advances in experimental medicine and biology
#1,914
of 4,976 outputs
Outputs of similar age
#220,405
of 442,670 outputs
Outputs of similar age from Advances in experimental medicine and biology
#61
of 237 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,976 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,670 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 237 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.