Chapter title |
The Molecular Biology of HIV Latency
|
---|---|
Chapter number | 8 |
Book title |
HIV Vaccines and Cure
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-13-0484-2_8 |
Pubmed ID | |
Book ISBNs |
978-9-81-130483-5, 978-9-81-130484-2
|
Authors |
Georges Khoury, Gilles Darcis, Michelle Y. Lee, Sophie Bouchat, Benoit Van Driessche, Damian F. J. Purcell, Carine Van Lint, Khoury, Georges, Darcis, Gilles, Lee, Michelle Y., Bouchat, Sophie, Driessche, Benoit Van, Purcell, Damian F. J., Lint, Carine Van |
Abstract |
HIV remains incurable due to the existence of a reservoir of cells that harbor intact integrated genomes of the virus in the absence of viral replication. This population of infected cells remains invisible to the immune system and is not targeted by the drugs used in the current antiretroviral therapies (cART). Reversal of latency by the use of inhibitors of chromatin-remodeling enzymes has been studied extensively in an attempt to purge this reservoir of latent HIV but has thus far not shown any success in clinical trials. The full complexity of latent HIV infection has still not been appreciated, and the gaps in knowledge prevent development of adequate small-molecule compounds that can effectively perturb this reservoir. In this review, we will examine the role of epigenetic silencing of HIV transcription, posttranscriptional regulation, and mRNA processing in promoting HIV-1 latency. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 71 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 12 | 17% |
Student > Bachelor | 11 | 15% |
Student > Ph. D. Student | 11 | 15% |
Researcher | 7 | 10% |
Student > Doctoral Student | 6 | 8% |
Other | 3 | 4% |
Unknown | 21 | 30% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 20 | 28% |
Medicine and Dentistry | 8 | 11% |
Agricultural and Biological Sciences | 7 | 10% |
Immunology and Microbiology | 6 | 8% |
Computer Science | 2 | 3% |
Other | 5 | 7% |
Unknown | 23 | 32% |