↓ Skip to main content

HIV Vaccines and Cure

Overview of attention for book
Attention for Chapter 3: HIV Broadly Neutralizing Antibodies: VRC01 and Beyond
Altmetric Badge

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
19 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
HIV Broadly Neutralizing Antibodies: VRC01 and Beyond
Chapter number 3
Book title
HIV Vaccines and Cure
Published in
Advances in experimental medicine and biology, January 2018
DOI 10.1007/978-981-13-0484-2_3
Pubmed ID
Book ISBNs
978-9-81-130483-5, 978-9-81-130484-2
Authors

Xueling Wu, Wu, Xueling

Abstract

Developing an effective prophylaxis HIV-1 vaccine is likely to require the elicitation of broadly neutralizing antibodies (bnAbs). As the HIV-1 envelope (Env) glycoprotein - the sole target of bnAbs - has evolved multiple mechanisms to evade antibody neutralization, the processes for bnAb generation are highly selective and time-consuming. Benefiting from antibody isolation technologies of single B cell culturing and direct single B cell sorting and cloning, a new generation of monoclonal bnAbs has been isolated since 2009, exhibiting remarkable breadths and potencies, thus breaking through a nearly 20-year-long limit of four monoclonal bnAbs with moderate breadth and potency. The discovery of a long list of monoclonal bnAbs has provided in-depth understanding of the sites of vulnerability on the HIV-1 Env and the complexity of human B cell immunology to generate such responses, thus presenting both guidance and challenges to move the Env immunogen design effort forward.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 16%
Student > Ph. D. Student 3 16%
Professor 1 5%
Student > Master 1 5%
Researcher 1 5%
Other 2 11%
Unknown 8 42%
Readers by discipline Count As %
Immunology and Microbiology 4 21%
Biochemistry, Genetics and Molecular Biology 3 16%
Agricultural and Biological Sciences 1 5%
Engineering 1 5%
Unknown 10 53%