Chapter title |
Immunohistochemistry for Triple-Negative Breast Cancer.
|
---|---|
Chapter number | 3 |
Book title |
Breast Cancer
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3444-7_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3442-3, 978-1-4939-3444-7
|
Authors |
Naidoo, Kalnisha, Pinder, Sarah E, Kalnisha Naidoo, Sarah E. Pinder, Pinder, Sarah E. |
Abstract |
Triple-negative breast cancers are a heterogeneous group of tumors that are, as yet, not entirely understood. Although triple-negative carcinomas are strictly defined as invasive carcinomas lacking expression of estrogen receptor, progesterone receptor, and HER2, some use the terms triple-negative and basal-like cancer synonymously. It should be noted that these are not entirely equivalent. Nevertheless, it has been shown that a panel of immunohistochemical markers can be used as a surrogate for genomic profiling and thus to identify basal-like breast cancers. We describe the panels of immunohistochemical markers that can be applied and how to interpret these markers herein. |
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