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Non-Viral Gene Delivery Vectors

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Cover of 'Non-Viral Gene Delivery Vectors'

Table of Contents

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    Book Overview
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    Chapter 1 Physical Chemical and Biomolecular Methods for the Optimization of Cationic Lipid-Based Lipoplexes In Vitro for the Gene Therapy Applications
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    Chapter 2 Non-Viral Gene Delivery Vectors
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    Chapter 3 Lipoplexes from Non-viral Cationic Vectors: DOTAP-DOPE Liposomes and Gemini Micelles
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    Chapter 4 Anionic/Zwitterionic Lipid-Based Gene Vectors of pDNA
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    Chapter 5 Elaboration and Physicochemical Characterization of Niosome-Based Nioplexes for Gene Delivery Purposes
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    Chapter 6 Quantitative Intracellular Localization of Cationic Lipid–Nucleic Acid Nanoparticles with Fluorescence Microscopy
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    Chapter 7 Targeted Delivery of Peptide-Tagged DNA Lipoplexes to Hepatocellular Carcinoma Cells
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    Chapter 8 Lipoplexes Strengthened by Anionic Polymers: Easy Preparation of Highly Effective siRNA Vectors Based on Cationic Lipids and Anionic Polymers
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    Chapter 9 Polymer Based Gene Silencing: In Vitro Delivery of SiRNA
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    Chapter 10 Polyallylamine Derivatives: Novel NonToxic Transfection Agents
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    Chapter 11 Biodegradable Three-Layered Micelles and Injectable Hydrogels
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    Chapter 12 Non-Viral Gene Delivery Vectors
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    Chapter 13 Non-Viral Gene Delivery Vectors
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    Chapter 14 Characterization and Investigation of Redox-Sensitive Liposomes for Gene Delivery
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    Chapter 15 From Artificial Amino Acids to Sequence-Defined Targeted Oligoaminoamides
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    Chapter 16 Gene Delivery Method Using Photo-Responsive Poly(β-Amino Ester) as Vectors
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    Chapter 17 Thermo-Responsive Polyplex Micelles with PEG Shells and PNIPAM Layer to Protect DNA Cores for Systemic Gene Therapy
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    Chapter 18 Application of Polyethylenimine-Grafted Silicon Nanowire Arrays for Gene Transfection
Attention for Chapter 15: From Artificial Amino Acids to Sequence-Defined Targeted Oligoaminoamides
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Chapter title
From Artificial Amino Acids to Sequence-Defined Targeted Oligoaminoamides
Chapter number 15
Book title
Non-Viral Gene Delivery Vectors
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3718-9_15
Pubmed ID
Book ISBNs
978-1-4939-3716-5, 978-1-4939-3718-9
Authors

Stephan Morys, Ernst Wagner, Ulrich Lächelt

Abstract

Artificial oligoamino acids with appropriate protecting groups can be used for the sequential assembly of oligoaminoamides on solid-phase. With the help of these oligoamino acids multifunctional nucleic acid (NA) carriers can be designed and produced in highly defined topologies. Here we describe the synthesis of the artificial oligoamino acid Fmoc-Stp(Boc3)-OH, the subsequent assembly into sequence-defined oligomers and the formulation of tumor-targeted plasmid DNA (pDNA) polyplexes.

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Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 13%
Student > Ph. D. Student 1 13%
Researcher 1 13%
Lecturer 1 13%
Unknown 4 50%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 25%
Nursing and Health Professions 1 13%
Chemistry 1 13%
Unknown 4 50%