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Mendeley readers
Chapter title |
Lipoplexes from Non-viral Cationic Vectors: DOTAP-DOPE Liposomes and Gemini Micelles
|
---|---|
Chapter number | 3 |
Book title |
Non-Viral Gene Delivery Vectors
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3718-9_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3716-5, 978-1-4939-3718-9
|
Authors |
Sara Falsini, Sandra Ristori |
Abstract |
This chapter describes the topic of gene therapy based on colloidal drug delivery, as an alternative to the use of viral carriers. Non-viral vectors are promising transfection agents and do not suffer from limitations related to toxicity and immunogenic effects. In particular, lipid-based aggregates are generally considered biocompatible and versatile nanocarriers whose composition can be designed to include a cationic molecule which ensures strong interaction with nucleic acid. Herein the main issues related to complex formation and in vitro administration are illustrated with key examples, such as liposome-DNA plasmid (pDNA) association and micelles-siRNA complexes. |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 27% |
Professor | 2 | 18% |
Researcher | 2 | 18% |
Student > Ph. D. Student | 2 | 18% |
Student > Doctoral Student | 1 | 9% |
Other | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 4 | 36% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 27% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Unspecified | 1 | 9% |
Unknown | 2 | 18% |