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T-Cell Development

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Cover of 'T-Cell Development'

Table of Contents

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    Book Overview
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    Chapter 1 T-Cell Development
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    Chapter 2 Development of γδ T Cells, the Special-Force Soldiers of the Immune System
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    Chapter 3 Genetic Tools to Study T Cell Development
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    Chapter 4 Assessment of T Cell Development by Flow Cytometry
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    Chapter 5 Flow Cytometry Analysis of Thymic Epithelial Cells and Their Subpopulations.
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    Chapter 6 Identifying the Spatial Relationships of Thymic Stromal and Thymocyte Subsets by Immunofluorescence Analysis.
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    Chapter 7 Purification of Thymocyte and T Cell Subsets
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    Chapter 8 Retroviral Transduction of T Cells and T Cell Precursors
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    Chapter 9 T-Cell Development
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    Chapter 10 In Vitro Analyses of T Cell Effector Differentiation
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    Chapter 11 Studying T Cell Development in Thymic Slices
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    Chapter 12 FTOC-Based Analysis of Negative Selection.
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    Chapter 13 Reconstituted Thymus Organ Culture
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    Chapter 14 Induction of T Cell Development In Vitro by Delta-Like (Dll)-Expressing Stromal Cells
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    Chapter 15 In Vitro Analysis of Thymocyte Signaling
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    Chapter 16 Molecular Analysis of Mouse T Cell Receptor α and β Gene Rearrangements.
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    Chapter 17 Intrathymic Injection
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    Chapter 18 Analysis of Cell Proliferation and Homeostasis Using EdU Labeling
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    Chapter 19 Characterization and Isolation of Human T Cell Progenitors
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    Chapter 20 Approaches to Study Human T Cell Development
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    Chapter 21 Humanized Mice to Study Human T Cell Development.
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    Chapter 22 Using the Zebrafish Model to Study T Cell Development.
Attention for Chapter 2: Development of γδ T Cells, the Special-Force Soldiers of the Immune System
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Chapter title
Development of γδ T Cells, the Special-Force Soldiers of the Immune System
Chapter number 2
Book title
T-Cell Development
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-2809-5_2
Pubmed ID
Book ISBNs
978-1-4939-2808-8, 978-1-4939-2809-5
Authors

David L. Wiest

Abstract

While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated by αβ T cells. Accordingly, it is essential to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will cover the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 29%
Student > Bachelor 3 18%
Student > Master 2 12%
Professor 1 6%
Unspecified 1 6%
Other 1 6%
Unknown 4 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 24%
Immunology and Microbiology 3 18%
Biochemistry, Genetics and Molecular Biology 3 18%
Unspecified 1 6%
Medicine and Dentistry 1 6%
Other 1 6%
Unknown 4 24%