Chapter title |
Genetic Tools to Study T Cell Development
|
---|---|
Chapter number | 3 |
Book title |
T-Cell Development
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-2809-5_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2808-8, 978-1-4939-2809-5
|
Authors |
Thomas Ciucci, Melanie S. Vacchio, Rémy Bosselut |
Abstract |
Genetics tools, and especially the ability to enforce, by transgenesis, or disrupt, by homologous recombination, gene expression in a cell-specific manner, have revolutionized the study of immunology and propelled the laboratory mouse as the main model to study immune responses. Perhaps more than any other aspect of immunology, the study of T cell development has benefited from these technologies. This brief chapter summarizes genetic tools specific to T cell development studies, focusing on mouse strains with lineage- and stage-specific expression of the Cre recombinase, or expressing unique antigen receptor specificities. It ends with a broader discussion of strategies to enforce ectopic lineage and stage-specific gene expression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 1 | 17% |
Lecturer | 1 | 17% |
Student > Bachelor | 1 | 17% |
Professor | 1 | 17% |
Student > Ph. D. Student | 1 | 17% |
Other | 0 | 0% |
Unknown | 1 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Nursing and Health Professions | 1 | 17% |
Agricultural and Biological Sciences | 1 | 17% |
Immunology and Microbiology | 1 | 17% |
Medicine and Dentistry | 1 | 17% |
Engineering | 1 | 17% |
Other | 0 | 0% |
Unknown | 1 | 17% |