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3D Sponge-Matrix Histoculture

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Cover of '3D Sponge-Matrix Histoculture'

Table of Contents

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    Book Overview
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    Chapter 1 In Memoriam: Joseph Leighton, 1921–1999—Father of 3-Dimensional Tissue Culture
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    Chapter 2 3D Sponge-Matrix Histoculture: An Overview
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    Chapter 3 In Vivo-Like Growth Patterns of Multiple Types of Tumors in Gelfoam® Histoculture
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    Chapter 4 Expression and Targeting of Tumor Markers in Gelfoam® Histoculture: Potential Individualized Assays for Immuno-Oncology
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    Chapter 5 Development of the Histoculture Drug Response Assay (HDRA)
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    Chapter 6 Diagnosis and Pathological Analysis of Patient Cancers by Detection of Proliferating Cells in Gelfoam® Histoculture
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    Chapter 7 Clinical Correlation of the Histoculture Drug Response Assay in Gastrointestinal Cancer
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    Chapter 8 Prospective Clinical Correlation of the Histoculture Drug Response Assay for Ovarian Cancer
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    Chapter 9 Clinical Correlation of the Histoculture Drug Response Assay for Head and Neck Cancer
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    Chapter 10 Clinical Usefulness of the Histoculture Drug Response Assay for Breast Cancer
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    Chapter 11 Clinical Usefulness of the Histoculture Drug Response Assay for Prostate Cancer and Benign Prostate Hypertrophy (BPH)
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    Chapter 12 In Vivo-Like Cell-Cycle Phase Distribution of Cancer Cells in Gelfoam® Histoculture Observed in Real Time by FUCCI Imaging
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    Chapter 13 Methionine Dependency Determination of Human Patient Tumors in Gelfoam® Histoculture
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    Chapter 14 Hair-Shaft Growth in Gelfoam® Histoculture of Skin and Isolated Hair Follicles
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    Chapter 15 Hair Follicle-Associated Pluripotent (HAP) Stem Cells in Gelfoam® Histoculture for Use in Spinal Cord Repair
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    Chapter 16 Nerve Growth and Interaction in Gelfoam® Histoculture: A Nervous System Organoid
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    Chapter 17 Histoculture and Infection with HIV of Functional Human Lymphoid Tissue on Gelfoam®
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    Chapter 18 Imaging DNA Repair After UV Irradiation Damage of Cancer Cells in Gelfoam® Histoculture
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    Chapter 19 Comparison of “Dimensionality” of Cancer Cell Culture in Gelfoam® Histoculture and Matrigel
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    Chapter 20 Imaging the Governing Step of Metastasis in Gelfoam® Histoculture
Attention for Chapter 6: Diagnosis and Pathological Analysis of Patient Cancers by Detection of Proliferating Cells in Gelfoam® Histoculture
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Chapter title
Diagnosis and Pathological Analysis of Patient Cancers by Detection of Proliferating Cells in Gelfoam® Histoculture
Chapter number 6
Book title
3D Sponge-Matrix Histoculture
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7745-1_6
Pubmed ID
Book ISBNs
978-1-4939-7743-7, 978-1-4939-7745-1
Authors

Robert M. Hoffman

Abstract

Patient tumors grew in Gelfoam® histoculture with maintenance of tissue architecture, tumor-stromal interaction, and differentiated functions. In this chapter, we review the use of Gelfoam® histoculture to demonstrate proliferation indices of major solid cancer types explanted directly from surgery. Cell proliferation was visualized by histological autoradiography within the cultured tissues after [3H]thymidine incorporation by the proliferating cells. Epilumination polarization microscopy enables high-resolution imaging of the autoradiography of each cell. The histological status of the cultured tissues can be assessed simultaneously with the proliferation status. Carcinomas were observed to have areas of high epithelial proliferation with quiescent stromal cells. Sarcomas have high proliferation of the cancer cells of mesenchymal organ. Normal tissues can also proliferate at high rates. Mean growth fraction index (GFI) was highest for patient tumors with the pure subtype of small-cell lung cancer than other types of lung cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 1 100%
Readers by discipline Count As %
Immunology and Microbiology 1 100%