Chapter title |
Anti-inflammatory Effects of Galactose-Taurine Sodium Salt: A Taurine Derivate in Zebrafish In Vivo Model
|
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Chapter number | 51 |
Book title |
Taurine 10
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1079-2_51 |
Pubmed ID | |
Book ISBNs |
978-9-40-241077-8, 978-9-40-241079-2
|
Authors |
Eun A. Kim, WonWoo Lee, Ju Hyung Um, Nalae Kang, Sun Hee Cheong, Jae Young Oh, Kyung Ja Chang, Sung Hoon Kim, Soo Yeon Park, Eui Jeong Han, You-Jin Jeon, Ginnae Ahn |
Abstract |
Taurine, the plentiful amino acids in mammalian cells exerts various biological activities including antioxidant and anti-inflammatory effects. Inflammation can cause several diseases such as cancer, heart disease, rheumatoid arthritis and immune system reactions. Here, we investigated anti-inflammatory effects of Galactose-Taurine sodium salt (Gal-Tau), a newly synthesized taurine derivate in LPS-stimulated zebrafish embryos in vivo model. The result showed that Gal-Tau improved the survival rate and the edema in LPS-treated zebrafish embryos. Also, Gal-Tau effectively reduced the productions of nitric oxide (NO), reactive oxygen species (ROS) and cell death induced by LPS in zebrafish embryos. In addition, Gal-Tau regulated the expression levels of inflammatory mediators such as inducible NOS (iNOS) and cycloxygenase 2 (COX-2) as well as IL-6 and TNF-α, inflammatory cytokines known as important key mediators of inflammation. Taken together, this study first indicates that Gal-Tau could be considered as an effective anti-inflammatory material with its anti-inflammatory activity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 19% |
Student > Master | 3 | 19% |
Researcher | 2 | 13% |
Other | 1 | 6% |
Professor | 1 | 6% |
Other | 3 | 19% |
Unknown | 3 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 19% |
Veterinary Science and Veterinary Medicine | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Medicine and Dentistry | 2 | 13% |
Nursing and Health Professions | 1 | 6% |
Other | 2 | 13% |
Unknown | 4 | 25% |