Chapter title |
Protective Effect of Taurine on Mice with Doxorubicin-induced Acute Kidney Injury
|
---|---|
Chapter number | 95 |
Book title |
Taurine 10
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1079-2_95 |
Pubmed ID | |
Book ISBNs |
978-9-40-241077-8, 978-9-40-241079-2
|
Authors |
Yon-Suk Kim, Si-Heung Sung, Yujiao Tang, Eun-Ju Choi, Young-Jin Choi, Young Joung Hwang, Pyo-Jam Park, Eun-Kyung Kim, Kim, Yon-Suk, Sung, Si-Heung, Tang, Yujiao, Choi, Eun-Ju, Choi, Young-Jin, Hwang, Young Joung, Park, Pyo-Jam, Kim, Eun-Kyung |
Abstract |
Nephrotic syndrome is still a therapeutic challenge because an effective treatment has not been developed. Evidence suggests that multidrug therapy is more effective than monotherapy in amelioration of renal injury. Therefore, we examined if taurine exerts a protective effect on doxorubicin-induced acute kidney injury in mice. Eight-week-old male Balb/c nude mice were used in this study. Taurine was orally administered at a dose of 50 mg/kg and 100 mg/kg body weight for 5 days. In the meantime, the mice were administered intraperitoneal injections of doxorubicin at 15 mg/kg body weight. At 24 h after the doxorubicin challenge, the response in the taurine-treated mice was compared with that in the vehicle-treated control mice. The doxorubicin-induced acute kidney injury model displayed a significant increase in the renal expression of apoptosis-related proteins (p53, phospho-p53, caspase 9, and caspase 3), whereas in the taurine-treated mice, the augmented expression of renal inflammation-related mRNAs such as NF-kB, COX-2, and iNOS was down-regulated. These results suggest that taurine acts as a renoprotective agent by inhibiting apoptosis and inflammation in the kidney of mice with doxorubicin-induced renal injury. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 21% |
Student > Bachelor | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
Student > Master | 2 | 14% |
Other | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 21% |
Agricultural and Biological Sciences | 2 | 14% |
Chemistry | 2 | 14% |
Nursing and Health Professions | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 29% |