Chapter title |
Comparative Analysis of Microbicidal and Anti-inflammatory Properties of Novel Taurine Bromamine Derivatives and Bromamine T
|
---|---|
Chapter number | 41 |
Book title |
Taurine 10
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1079-2_41 |
Pubmed ID | |
Book ISBNs |
978-9-40-241077-8, 978-9-40-241079-2
|
Authors |
M. Walczewska, A. Peruń, A. Białecka, M. Śróttek, W. Jamróz, P. Dorożyński, R. Jachowicz, P. Kulinowski, M. Nagl, W. Gottardi, J. Marcinkiewicz |
Abstract |
Taurine, the most abundant free amino acid in leukocyte cytosol traps hypohalous acids (HOCl and HOBr) to produce N-chlorotaurine (taurine chloramine, NCT and N-bromotaurine (taurine bromamine, Tau-NHBr,) respectively. Both haloamines show anti-inflammatory and antimicrobial properties. However, the therapeutic applicability of Tau-NHBr is limited due to its relatively poor stability. To overcome this disadvantage, we have synthesized the stable N-bromotaurine compounds N-monobromo-2,2-dimethyltaurine (Br-612) and N-dibromo-2,2-dimethyltaurine (Br-422). The aim of this study was to compare anti-inflammatory and microbicidal properties of Br-612 and Br-422 with that of Tau-NHBr and bromamine T (BAT). We have shown that all the tested compounds show similar anti-inflammatory properties. Importantly, the stable N-bromotaurine compounds exerted even stronger microbicidal activity than Tau-NHBr. Finally, for the purpose of topical application of these compounds we have developed a carbomer-based bioadhesive solid dosage form of BAT and Br-612, featuring sustained release of the active substance. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 36% |
Professor > Associate Professor | 3 | 27% |
Student > Bachelor | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Unknown | 2 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 1 | 9% |
Immunology and Microbiology | 1 | 9% |
Physics and Astronomy | 1 | 9% |
Other | 2 | 18% |
Unknown | 4 | 36% |