Chapter title |
Xylose-Taurine Reduced Suppresses the Inflammatory Responses in Lipopolysaccharide-Stimulated Raw264.7 Macrophages
|
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Chapter number | 49 |
Book title |
Taurine 10
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1079-2_49 |
Pubmed ID | |
Book ISBNs |
978-9-40-241077-8, 978-9-40-241079-2
|
Authors |
WonWoo Lee, Nalae Kang, Soo Yeon Park, Sun Hee Cheong, Kyung Ja Chang, Sung Hoon Kim, Ju Hyung Um, Eui Jeong Han, Eun A. Kim, You-Jin Jeon, Ginnae Ahn |
Abstract |
Here, the anti-inflammatory effect of Xylose-Taurine reduced (X-T-R), a taurine derivate was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. X-T-R reduced the generations of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by the stimulation of LPS in RAW 264.7 by suppressing the protein expression of iNOS and COX-2 known as inflammatory mediators. Also, X-R-T reduced the expression levels of the pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF-α). Moreover, X-T-R inhibited the activation of nuclear factor-κB (NF-κB) and the phosphorylation of inhibitor κB (IκB)-α. In conclusion, these results first indicate that X-T-R inhibits LPS-induced inflammation by regulating the NF-κB signal pathway in macrophages. |
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Unknown | 13 | 100% |
Demographic breakdown
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Student > Master | 3 | 23% |
Other | 2 | 15% |
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Student > Bachelor | 1 | 8% |
Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Other | 1 | 8% |
Unknown | 4 | 31% |