Chapter title |
Anti-inflammatory Effects of Galactose-Taurine Sodium Salt in LPS-Activated RAW 264.7 Cells
|
---|---|
Chapter number | 75 |
Book title |
Taurine 10
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1079-2_75 |
Pubmed ID | |
Book ISBNs |
978-9-40-241077-8, 978-9-40-241079-2
|
Authors |
Nalae Kang, Kyung Ja Chang, Soo Yeon Park, Ju Hyung Um, Eui Jeong Han, WonWoo Lee, Eun A. Kim, Jae Young Oh, Sung Hoon Kim, You-Jin Jeon, Chang-Bum Ahn, Sun Hee Cheong, Ginnae Ahn |
Abstract |
In this study, we synthesized Galactose-Taurine sodium salt (G-T) as a functional food ingredient to enhance biological activities of taurine. Also, anti-inflammatory effects of G-T were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. G-T found to reduce the generations of the LPS-stimulated nitric oxide (NO) and prostaglandin E2 (PGE2) via down-regulating the expression levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). Also, G-T reduced the secretion of inflammatory cytokines including interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF-α) in LPS-treated RAW 264.7 cells. Finally, we identified that G-T inhibits the activation of nuclear factor-κB (NF-κB) and the phosphorylation of inhibitor κB (IκB)-α. From these results, this study first suggests that G-T could be considered as an effective anti-inflammatory agent. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 27% |
Student > Master | 2 | 18% |
Other | 1 | 9% |
Lecturer > Senior Lecturer | 1 | 9% |
Professor | 1 | 9% |
Other | 1 | 9% |
Unknown | 2 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 27% |
Nursing and Health Professions | 1 | 9% |
Veterinary Science and Veterinary Medicine | 1 | 9% |
Neuroscience | 1 | 9% |
Chemistry | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |