Chapter title |
Taurine Attenuates As 2 O 3 -Induced Autophagy in Cerebrum of Mouse Through Nrf2 Pathway
|
---|---|
Chapter number | 68 |
Book title |
Taurine 10
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1079-2_68 |
Pubmed ID | |
Book ISBNs |
978-9-40-241077-8, 978-9-40-241079-2
|
Authors |
Fengyuan Piao, Yan Zhang, Lijun Yang, Cong Zhang, Jing Shao, Xiaohui Liu, Yachen Li, Shuangyue Li, Piao, Fengyuan, Zhang, Yan, Yang, Lijun, Zhang, Cong, Shao, Jing, Liu, Xiaohui, Li, Yachen, Li, Shuangyue |
Abstract |
We previously reported that the impairment of cerebrum may relate with neurotoxicity induced by arsenic (As) exposure. In the present study, we investigated whether autophagy of the cerebrum neurons were responsible for As-induced neurotoxicity and the protective role of taurine (Tau). Forty mice were randomly divided into control group, Tau control group, As exposure group and Tau protection group. The results showed that LC3 II expression was elevated and P62 expression was lower after As exposure, whereas the effects were obviously attenuated by Tau treatment. More important, As induced increase of MDA level and decrease of Nrf2 expression were significantly inversed in protective group. In sum, autophagy inhibition might play a strong role in the neuroprotection of Tau in As-induced toxicity via Nrf2 pathway. |
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