Chapter title |
Taurine Attenuates Epithelial-Mesenchymal Transition-Related Genes in Human Prostate Cancer Cells
|
---|---|
Chapter number | 96 |
Book title |
Taurine 10
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1079-2_96 |
Pubmed ID | |
Book ISBNs |
978-9-40-241077-8, 978-9-40-241079-2
|
Authors |
Yujiao Tang, Yon-Suk Kim, Eun-Ju Choi, Young Joung Hwang, Yeong Sik Yun, Sung Mun Bae, Pyo-Jam Park, Eun-Kyung Kim, Tang, Yujiao, Kim, Yon-Suk, Choi, Eun-Ju, Hwang, Young Joung, Yun, Yeong Sik, Bae, Sung Mun, Park, Pyo-Jam, Kim, Eun-Kyung |
Abstract |
Prostate cancer is the most common non-cutaneous cancers among men and the second leading cause of cancer-related deaths among men. Aberrant activation of the epithelial to mesenchymal transition (EMT) has been exhibited to be one of the most common causes of treatment failure and death in cancer patients. In cancer cells with metastatic competence, the E-cadherin switch is a well-established hallmark. Suppression of E-cadherin through its transcriptional repressor SNAIL is thus a determining factor for EMT. TWIST1 is an important transcription factor in EMT, which is present under both physiologic (embryogenesis) and pathologic (metastasis) conditions, and enhances the invasiveness and migration ability of cells. In this study, we investigated the inhibitory effects of taurine on EMT-related genes, such as E-cadherin, N-cadherin, TWIST1, ZEB1, SNAIL, and vimentin. EMT markers were detected by RT-PCR and western blotting. The results showed that taurine down-regulated the expression of N-cadherin, TWIST1, ZEB1, SNAIL, and vimentin. In contrast, taurine increased E-cadherin expression. Our findings indicate that taurine has EMT inhibitory effects on human prostate cancer cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 2 | 8% |
Student > Ph. D. Student | 1 | 4% |
Researcher | 1 | 4% |
Professor > Associate Professor | 1 | 4% |
Unknown | 21 | 81% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 2 | 8% |
Psychology | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Medicine and Dentistry | 1 | 4% |
Engineering | 1 | 4% |
Other | 0 | 0% |
Unknown | 20 | 77% |