Chapter title |
Taurine Protects Mouse Liver Against Arsenic-Induced Apoptosis Through JNK Pathway
|
---|---|
Chapter number | 67 |
Book title |
Taurine 10
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1079-2_67 |
Pubmed ID | |
Book ISBNs |
978-9-40-241077-8, 978-9-40-241079-2
|
Authors |
Shuangxing Li, Lijun Yang, Guangtao Dong, Xiujie Wang |
Abstract |
A great number of evidences demonstrated that the increased apoptosis is related to arsenic (As)-induced liver injury. The object of the present study was to explore the protection of taurine (Tau) against As-induced impairment in liver and the related mechanism. Adult mice were divided into control group, As exposure group and Tau protection group. The results of RT-PCR and WB showed that Tau treatment significantly reversed the disturbance of Bax and Bcl-2 expression. The release of cytochrome c and caspase-3 activation in liver both were prohibited by Tau in As-intoxicated mice. Furthermore, Tau markedly attenuated As-induced decrease of p-JNK level in mouse liver. These results indicated that Tau attenuated As-induced hepatic injury via JNK pathway. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 2 | 15% |
Student > Ph. D. Student | 2 | 15% |
Other | 1 | 8% |
Lecturer | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 5 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 23% |
Biochemistry, Genetics and Molecular Biology | 2 | 15% |
Neuroscience | 1 | 8% |
Psychology | 1 | 8% |
Unknown | 6 | 46% |