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Viruses, Genes, and Cancer

Overview of attention for book
Attention for Chapter 34: MicroRNA Dysregulation to Identify Novel Therapeutic Targets
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Chapter title
MicroRNA Dysregulation to Identify Novel Therapeutic Targets
Chapter number 34
Book title
Viruses, Genes, and Cancer
Published in
Current topics in microbiology and immunology, January 2017
DOI 10.1007/82_2017_34
Pubmed ID
Book ISBNs
978-3-31-961803-6, 978-3-31-961804-3
Authors

Carlo M. Croce

Abstract

This paper describes how we discovered the juxtaposition of the MYC gene to the human immunoglobulin loci and how that finding was extended to characterize molecularly the t(14;18) chromosome translocation of follicular lymphoma and to clone the BCL2 gene. BCL2 is also overexpressed in CLL, the most common human leukemia. We discovered that most of human CLLs have a deletion of two microRNAs residing in the same polycistronic RNA, miR-15a and miR-16-1, and that these two microRNAs are negative regulators of BCL2. Thus, loss of miR-15/16 leads to overexpression of BCL2 that can be targeted by the new drug, venetoclax, that was recently approved by the FDA for the treatment of aggressive CLLs.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 43%
Student > Doctoral Student 1 14%
Other 1 14%
Student > Ph. D. Student 1 14%
Student > Bachelor 1 14%
Other 0 0%
Readers by discipline Count As %
Medicine and Dentistry 4 57%
Chemistry 1 14%
Unknown 2 29%