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Mendeley readers
| Chapter title |
MicroRNA Dysregulation to Identify Novel Therapeutic Targets
|
|---|---|
| Chapter number | 34 |
| Book title |
Viruses, Genes, and Cancer
|
| Published in |
Current topics in microbiology and immunology, January 2017
|
| DOI | 10.1007/82_2017_34 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-961803-6, 978-3-31-961804-3
|
| Authors |
Carlo M. Croce |
| Abstract |
This paper describes how we discovered the juxtaposition of the MYC gene to the human immunoglobulin loci and how that finding was extended to characterize molecularly the t(14;18) chromosome translocation of follicular lymphoma and to clone the BCL2 gene. BCL2 is also overexpressed in CLL, the most common human leukemia. We discovered that most of human CLLs have a deletion of two microRNAs residing in the same polycistronic RNA, miR-15a and miR-16-1, and that these two microRNAs are negative regulators of BCL2. Thus, loss of miR-15/16 leads to overexpression of BCL2 that can be targeted by the new drug, venetoclax, that was recently approved by the FDA for the treatment of aggressive CLLs. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 43% |
| Student > Doctoral Student | 1 | 14% |
| Other | 1 | 14% |
| Student > Ph. D. Student | 1 | 14% |
| Student > Bachelor | 1 | 14% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 57% |
| Chemistry | 1 | 14% |
| Unknown | 2 | 29% |