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Viruses, Genes, and Cancer

Overview of attention for book
Attention for Chapter 6: Oncogenic Roles of the PI3K/AKT/mTOR Axis
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2 tweeters

Citations

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3 Dimensions

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68 Mendeley
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Chapter title
Oncogenic Roles of the PI3K/AKT/mTOR Axis
Chapter number 6
Book title
Viruses, Genes, and Cancer
Published in
Current topics in microbiology and immunology, May 2017
DOI 10.1007/82_2017_6
Pubmed ID
Book ISBNs
978-3-31-961803-6, 978-3-31-961804-3
Authors

Aoki, Masahiro, Fujishita, Teruaki, Masahiro Aoki, Teruaki Fujishita

Abstract

The PI3K/AKT/mTOR pathway is frequently activated in various human cancers and has been considered a promising therapeutic target. Many of the positive regulators of the PI3K/AKT/mTOR axis, including the catalytic (p110α) and regulatory (p85α), of class IA PI3K, AKT, RHEB, mTOR, and eIF4E, possess oncogenic potentials, as demonstrated by transformation assays in vitro and by genetically engineered mouse models in vivo. Genetic evidences also indicate their roles in malignancies induced by activation of the upstream oncoproteins including receptor tyrosine kinases and RAS and those induced by the loss of the negative regulators of the PI3K/AKT/mTOR pathway such as PTEN, TSC1/2, LKB1, and PIPP. Possible mechanisms by which the PI3K/AKT/mTOR axis contributes to oncogenic transformation include stimulation of proliferation, survival, metabolic reprogramming, and invasion/metastasis, as well as suppression of autophagy and senescence. These phenotypic changes are mediated by eIF4E-induced translation of a subset of mRNAs and by other downstream effectors of mTORC1 including S6K, HIF-1α, PGC-1α, SREBP, and ULK1 complex.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 15%
Researcher 7 10%
Student > Ph. D. Student 7 10%
Student > Master 6 9%
Student > Doctoral Student 5 7%
Other 13 19%
Unknown 20 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 29%
Medicine and Dentistry 11 16%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Agricultural and Biological Sciences 3 4%
Immunology and Microbiology 2 3%
Other 4 6%
Unknown 24 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2017.
All research outputs
#13,854,045
of 17,364,317 outputs
Outputs from Current topics in microbiology and immunology
#443
of 599 outputs
Outputs of similar age
#203,394
of 277,238 outputs
Outputs of similar age from Current topics in microbiology and immunology
#1
of 1 outputs
Altmetric has tracked 17,364,317 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 599 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,238 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them