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Viruses, Genes, and Cancer

Overview of attention for book
Attention for Chapter 35: Sequencing the Biology of Entry: The Retroviral env Gene
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Mentioned by

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2 tweeters

Citations

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3 Dimensions

Readers on

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9 Mendeley
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Chapter title
Sequencing the Biology of Entry: The Retroviral env Gene
Chapter number 35
Book title
Current Topics in Microbiology and Immunology
Published in
Current topics in microbiology and immunology, July 2017
DOI 10.1007/82_2017_35
Pubmed ID
Book ISBNs
978-3-31-961803-6, 978-3-31-961804-3
Authors

Swanstrom, Ronald, Graham, William D., Zhou, Shuntai, Ronald Swanstrom, William D. Graham, Shuntai Zhou

Abstract

The surface envelope protein of any virus is major determinant of the host cell that is infected and as a result a major determinant of viral pathogenesis. Retroviruses have a single surface protein named Env. It is a trimer of heterodimers and is responsible for binding to the host cell receptor and mediating fusion between the viral and host membranes. In this review we will discuss the history of the discovery of the avian leukosis virus (ALV) and human immunodeficiency virus type 1 (HIV-1) Env proteins and their receptor specificity, comparing the many differences but having some similarities. Much of the progress in these fields has relied on viral genetics and genetic polymorphisms in the host population. A special feature of HIV-1 is that its persistent infection in its human host, to the point of depleting its favorite target cells, allows the virus to evolve new entry phenotypes to expand its host range into several new cell types. This variety of entry phenotypes has led to confusion in the field leading to the major form of entry phenotype of HIV-1 being overlooked until recently. Thus an important part of this story is the description and naming of the most abundant entry form of the virus: R5 T cell-tropic HIV-1.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 22%
Professor > Associate Professor 1 11%
Researcher 1 11%
Other 1 11%
Unknown 4 44%
Readers by discipline Count As %
Immunology and Microbiology 3 33%
Biochemistry, Genetics and Molecular Biology 1 11%
Medicine and Dentistry 1 11%
Unknown 4 44%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2017.
All research outputs
#18,112,940
of 22,406,829 outputs
Outputs from Current topics in microbiology and immunology
#519
of 672 outputs
Outputs of similar age
#215,852
of 285,404 outputs
Outputs of similar age from Current topics in microbiology and immunology
#1
of 1 outputs
Altmetric has tracked 22,406,829 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 672 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,404 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them