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Mendeley readers
Chapter title |
Syntheses of Human TLR8-Specific Small-Molecule Agonists
|
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Chapter number | 3 |
Book title |
Vaccine Adjuvants
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Published in |
Methods in molecular biology, October 2016
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DOI | 10.1007/978-1-4939-6445-1_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6443-7, 978-1-4939-6445-1
|
Authors |
Mallesh Beesu, Hari Prasad Kokatla, Sunil A. David |
Editors |
Christopher B. Fox |
Abstract |
Human toll-like receptor (hTLR)-8 is expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. The synthetic procedures for best-in-class analogues encompassing four chemotypes are described. |
Mendeley readers
The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 2 | 67% |
Researcher | 1 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 1 | 33% |
Computer Science | 1 | 33% |
Chemistry | 1 | 33% |