Chapter title |
Quantification of Multiple Components of Complex Aluminum-Based Adjuvant Mixtures by Using Fourier Transform Infrared Spectroscopy and Partial Least Squares Modeling
|
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Chapter number | 18 |
Book title |
Vaccine Adjuvants
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Published in |
Methods in molecular biology, October 2016
|
DOI | 10.1007/978-1-4939-6445-1_18 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6443-7, 978-1-4939-6445-1
|
Authors |
Quinton M. Dowling, Ryan M. Kramer |
Editors |
Christopher B. Fox |
Abstract |
Fourier transform infrared (FTIR) spectroscopy is widely used in the pharmaceutical industry for process monitoring, compositional quantification, and characterization of critical quality attributes in complex mixtures. Advantages over other spectroscopic measurements include ease of sample preparation, quantification of multiple components from a single measurement, and the ability to quantify optically opaque samples. This method describes the use of a multivariate model for quantifying a TLR4 agonist (GLA) adsorbed onto aluminum oxyhydroxide (Alhydrogel(®)) using FTIR spectroscopy that may be adapted to quantify other complex aluminum based adjuvant mixtures. |
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Geographical breakdown
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Demographic breakdown
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Researcher | 2 | 50% |
Professor > Associate Professor | 1 | 25% |
Unknown | 1 | 25% |
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