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Chapter title |
Lyophilization of Adjuvanted Vaccines: Methods for Formulation of a Thermostable Freeze-Dried Product
|
---|---|
Chapter number | 15 |
Book title |
Vaccine Adjuvants
|
Published in |
Methods in molecular biology, October 2016
|
DOI | 10.1007/978-1-4939-6445-1_15 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6443-7, 978-1-4939-6445-1
|
Authors |
Michelle Y. Chan, Timothy S. Dutill, Ryan M. Kramer |
Editors |
Christopher B. Fox |
Abstract |
Lyophilization of vaccines is advantageous for the distribution and storage of thermally labile products, particularly in regions where cold chain management is difficult. To date, current lyophilized vaccines do not contain an adjuvant. Instead, adjuvanted vaccines may be presented as a two vial system, that require bedside-mixing prior to immunization. Here we present an example of a lyophilization cycle that we have used to successfully freeze-dry an adjuvanted protein formulation in a single vial. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 21% |
Student > Bachelor | 3 | 9% |
Researcher | 3 | 9% |
Student > Ph. D. Student | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 2 | 6% |
Unknown | 14 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Medicine and Dentistry | 3 | 9% |
Nursing and Health Professions | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Other | 4 | 12% |
Unknown | 15 | 45% |