Chapter title |
Evolution of Drug Resistance in Bacteria
|
---|---|
Chapter number | 5 |
Book title |
Biophysics of Infection
|
Published in |
Advances in experimental medicine and biology, May 2016
|
DOI | 10.1007/978-3-319-32189-9_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-932187-5, 978-3-31-932189-9
|
Authors |
Waclaw, B., B. Waclaw |
Editors |
Mark C. Leake |
Abstract |
Resistance to antibiotics is an important and timely problem of contemporary medicine. Rapid evolution of resistant bacteria calls for new preventive measures to slow down this process, and a longer-term progress cannot be achieved without a good understanding of the mechanisms through which drug resistance is acquired and spreads in microbial populations. Here, we discuss recent experimental and theoretical advances in our knowledge how the dynamics of microbial populations affects the evolution of antibiotic resistance . We focus on the role of spatial and temporal drug gradients and show that in certain situations bacteria can evolve de novo resistance within hours. We identify factors that lead to such rapid onset of resistance and discuss their relevance for bacterial infections. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | <1% |
Unknown | 106 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 16 | 15% |
Student > Master | 13 | 12% |
Researcher | 12 | 11% |
Student > Ph. D. Student | 12 | 11% |
Student > Doctoral Student | 4 | 4% |
Other | 9 | 8% |
Unknown | 41 | 38% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 19 | 18% |
Medicine and Dentistry | 10 | 9% |
Agricultural and Biological Sciences | 9 | 8% |
Engineering | 5 | 5% |
Immunology and Microbiology | 4 | 4% |
Other | 17 | 16% |
Unknown | 43 | 40% |