| Chapter title |
Force Spectroscopy in Studying Infection.
|
|---|---|
| Chapter number | 19 |
| Book title |
Biophysics of Infection
|
| Published in |
Advances in experimental medicine and biology, May 2016
|
| DOI | 10.1007/978-3-319-32189-9_19 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-932187-5, 978-3-31-932189-9
|
| Authors |
Zhaokun Zhou, Mark C. Leake |
| Editors |
Mark C. Leake |
| Abstract |
Biophysical force spectroscopy tools-for example, optical tweezers, magnetic tweezers, atomic force microscopy-have been used to study elastic, mechanical, conformational and dynamic properties of single biological specimens from single proteins to whole cells to reveal information not accessible by ensemble average methods such as X-ray crystallography, mass spectroscopy, gel electrophoresis and so on. Here, we review the application of these tools on a range of infection-related questions from antibody-inhibited protein processivity to virus-cell adhesion. In each case, we focus on how the instrumental design tailored to the biological system in question translates into the functionality suitable for that particular study. The unique insights that force spectroscopy has gained to complement knowledge learned through population averaging techniques in interrogating biomolecular details prove to be instrumental in therapeutic innovations such as those in structure-based drug design. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 38% |
| Student > Bachelor | 2 | 25% |
| Lecturer | 2 | 25% |
| Student > Postgraduate | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 38% |
| Chemical Engineering | 1 | 13% |
| Agricultural and Biological Sciences | 1 | 13% |
| Economics, Econometrics and Finance | 1 | 13% |
| Chemistry | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 1 | 13% |