Chapter title |
Discovering Functional ERK Substrates Regulating Caenorhabditis elegans Germline Development.
|
---|---|
Chapter number | 24 |
Book title |
ERK Signaling
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6424-6_24 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6422-2, 978-1-4939-6424-6
|
Authors |
Jessica Jie Chen, Swathi Arur Ph.D., Chen, Jessica Jie, Arur, Swathi, Swathi Arur |
Editors |
Gerardo Jimenez |
Abstract |
The Rat Sarcoma (RAS) GTPAse-mediated extracellular signal-regulated kinase (ERK) pathway regulates multiple biological processes across metazoans. In particular during Caenorhabditis elegans oogenesis, ERK signaling has been shown to regulate over seven distinct biological processes in a temporal and sequential manner. To fully elucidate how ERK signaling cascade orchestrates these different biological processes in vivo, identification of the direct functional substrates of the pathway is critical. This chapter describes the methods that were used to identify ERK substrates in a global manner and study their functions in the germline. These approaches can also be generally applied to study ERK-dependent biological processes in other systems. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 2 | 33% |
Student > Bachelor | 1 | 17% |
Lecturer | 1 | 17% |
Researcher | 1 | 17% |
Student > Master | 1 | 17% |
Other | 0 | 0% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 67% |
Biochemistry, Genetics and Molecular Biology | 1 | 17% |
Medicine and Dentistry | 1 | 17% |