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Mendeley readers
Chapter title |
Visualization of RAS/MAPK Signaling In Situ by the Proximity Ligation Assay (PLA).
|
---|---|
Chapter number | 14 |
Book title |
ERK Signaling
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Published in |
Methods in molecular biology, January 2017
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DOI | 10.1007/978-1-4939-6424-6_14 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6422-2, 978-1-4939-6424-6
|
Authors |
Zijian Tang, Chengkai Dai |
Editors |
Gerardo Jimenez |
Abstract |
RAS/MAPK signaling responds to diverse extracellular cues and regulates a wide array of cellular processes. Given its biological importance, abnormalities in RAS/MAPK signaling cascade have been intimately implicated in numerous human diseases, including cancer. Herein, we describe a novel methodology to study activation of this pivotal signaling pathway. The Proximity Ligation Assay (PLA) is employed to monitor kinase-substrate interactions between MEK1 and HSF1, or MEK1 and ERK1 in situ. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 2 | 25% |
Student > Ph. D. Student | 1 | 13% |
Researcher | 1 | 13% |
Unknown | 4 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 25% |
Agricultural and Biological Sciences | 1 | 13% |
Immunology and Microbiology | 1 | 13% |
Unknown | 4 | 50% |