Chapter title |
Gene Therapy of Salivary Diseases
|
---|---|
Chapter number | 6 |
Book title |
Oral Biology
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6685-1_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6683-7, 978-1-4939-6685-1
|
Authors |
Bruce J. Baum M.P.T.B., N.I.D.C.R., N.I.H., Sandra Afione, John A. Chiorini, Ana P. Cotrim, Corinne M. Goldsmith, Changyu Zheng, Bruce J. Baum |
Editors |
Gregory J. Seymour, Mary P. Cullinan, Nicholas C.K. Heng |
Abstract |
For many years, our research group worked to develop gene transfer approaches for salivary gland disorders that lacked effective conventional therapy. The purpose of this chapter is to describe and update key methods used in this process. As described in our original chapter from the 2010 volume, we focus on one clinical condition, irradiation-induced salivary hypofunction, and address the choice of transgene and vector to be used, the construction of recombinant viral vectors, how vector delivery is accomplished, and methods for assessing vector function in vitro and in an appropriate animal model. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 7% |
Canada | 1 | 7% |
Unknown | 13 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 40% |
Student > Bachelor | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Other | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Agricultural and Biological Sciences | 2 | 13% |
Medicine and Dentistry | 2 | 13% |
Psychology | 1 | 7% |
Other | 3 | 20% |
Unknown | 3 | 20% |