Report for: Rheumatoid Arthritis

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Chapter title	Generation of Specific Aptamers
Chapter number	11
Book title	Rheumatoid Arthritis
Published in	Methods in molecular biology, September 2018
DOI	10.1007/978-1-4939-8802-0_11
Pubmed ID	30244458
Book ISBNs	978-1-4939-8801-3, 978-1-4939-8802-0
Authors	Shuang Liu, Yasuyuki Suzuki, Makoto Inui
Abstract	Nucleic acid aptamers are therapeutic agents consisting of short single-strand DNA or RNA oligonucleotides, which have the ability to bind to target therapeutic molecules with high affinity and specificity, and have been developed as potent drugs for the treatment of rheumatoid arthritis. Aptamers have unique and advantageous features over antibodies, such as superior affinity with nano- or pico-molar dissociation constants, and ease of chemical synthesis, modification, and inactivation by designing antisense sequences. In this chapter, using a DNA-oligonucleotide pool, the technology of proteoliposome-systematic evolution of ligands by exponential enrichment (SELEX) is introduced. By using this technique, potential therapeutic agents with high affinity and specificity could be obtained.

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Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	4	100%

Demographic breakdown

Readers by professional status	Count	As %
Researcher	2	50%
Professor	1	25%
Unknown	1	25%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	2	50%
Unknown	2	50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2018.

All research outputs

#20,533,782

of 23,103,903 outputs

Outputs from Methods in molecular biology

#9,985

of 13,222 outputs

Outputs of similar age

#296,454

of 341,009 outputs

Outputs of similar age from Methods in molecular biology

#176

of 235 outputs

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So far Altmetric has tracked 13,222 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.

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Rheumatoid Arthritis

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Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context