Chapter title |
Collagen-Induced Arthritis Models
|
---|---|
Chapter number | 1 |
Book title |
Rheumatoid Arthritis
|
Published in |
Methods in molecular biology, September 2018
|
DOI | 10.1007/978-1-4939-8802-0_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8801-3, 978-1-4939-8802-0
|
Authors |
Maya Miyoshi, Shuang Liu |
Abstract |
Due to limitations of using patient-derived samples for systemic kinetic studies in rheumatoid arthritis (RA) research, animal models are helpful for further understanding the pathophysiology of RA and seeking potential therapeutic targets or strategies. The collagen-induced arthritis (CIA) model is one of the standard RA models used in preclinical research. The CIA model shares several pathological features with RA, such as breach of tolerance and generation of autoantibodies targeting collagen, synovial inflammatory cell infiltration, synovial hyperplasia, cartilage destruction, and bone erosion. In this chapter, a protocol for successful induction of CIA in mice is described. In this protocol, CIA is induced by active immunization by inoculation with type II heterologous collagen in Freund's adjuvant in susceptible DBA/1 mice. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 18% |
Professor | 1 | 6% |
Student > Master | 1 | 6% |
Researcher | 1 | 6% |
Student > Postgraduate | 1 | 6% |
Other | 0 | 0% |
Unknown | 10 | 59% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Medicine and Dentistry | 2 | 12% |
Computer Science | 1 | 6% |
Nursing and Health Professions | 1 | 6% |
Unknown | 11 | 65% |