Chapter title |
Release of Antibodies and Cytokines from B Cells
|
---|---|
Chapter number | 20 |
Book title |
Rheumatoid Arthritis
|
Published in |
Methods in molecular biology, September 2018
|
DOI | 10.1007/978-1-4939-8802-0_20 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8801-3, 978-1-4939-8802-0
|
Authors |
Shuang Liu |
Abstract |
Autoreactive B cells play a critical role in rheumatoid arthritis. These cells differentiate into long-living memory B cells and autoantibody-producing plasma cells and also present autoantigens to T cells to amplify misdirected immune responses. The therapeutic benefit of B-cell-deleting therapies suggests that B cells are emerging as important factors in the pathogenesis of RA. Aiming at evaluation of the function of B cells, which are usually derived from peripheral blood of RA patients and healthy donors, it is possible to conduct a series of experiments, such as in vitro assessment of antibody production and BCR-mediated cytokine release. These techniques can also be applied for in vivo application. |
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