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High Throughput Screening

Overview of attention for book
Cover of 'High Throughput Screening'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Design and Implementation of High-Throughput Screening Assays
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    Chapter 2 Characterization of Inhibitor Binding Through Multiple Inhibitor Analysis: A Novel Local Fitting Method
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    Chapter 3 High Throughput Screening
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    Chapter 4 Structure-Based Virtual Screening of Commercially Available Compound Libraries
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    Chapter 5 AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions
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    Chapter 6 Instrument Quality Control
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    Chapter 7 Application of Fluorescence Polarization in HTS Assays
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    Chapter 8 Time-Resolved Fluorescence Assays
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    Chapter 9 Protein Kinase Selectivity Profiling Using Microfluid Mobility Shift Assays
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    Chapter 10 Screening for Inhibitors of Kinase Autophosphorylation
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    Chapter 11 A Fluorescence-Based High-Throughput Screening Assay to Identify Growth Inhibitors of the Pathogenic Fungus Aspergillus fumigatus
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    Chapter 12 High Throughput Screening
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    Chapter 13 Identification of State-Dependent Blockers for Voltage-Gated Calcium Channels Using a FLIPR-Based Assay
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    Chapter 14 A Luciferase Reporter Gene System for High-Throughput Screening of γ -Globin Gene Activators
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    Chapter 15 A High-Throughput Flow Cytometry Assay for Identification of Inhibitors of 3′,5′-Cyclic Adenosine Monophosphate Efflux
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    Chapter 16 High-Throughput Cell Toxicity Assays
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    Chapter 17 BRET: NanoLuc-Based Bioluminescence Resonance Energy Transfer Platform to Monitor Protein-Protein Interactions in Live Cells
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    Chapter 18 Application of Imaging-Based Assays in Microplate Formats for High-Content Screening
Attention for Chapter 12: High Throughput Screening
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  • Good Attention Score compared to outputs of the same age and source (71st percentile)

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Chapter title
High Throughput Screening
Chapter number 12
Book title
High Throughput Screening
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3673-1_12
Pubmed ID
Book ISBNs
978-1-4939-3671-7, 978-1-4939-3673-1
Authors

White, E Lucile, Tower, Nichole A, Rasmussen, Lynn, E. Lucile White, Nichole A. Tower, Lynn Rasmussen, White, E. Lucile, Tower, Nichole A.

Abstract

High-throughput screening is a valuable way to identify hit compounds that combined with a robust medicinal chemistry program could lead to the identification of new antibiotics. Here, we discuss our method for screening large compound libraries with virulent Mycobacterium tuberculosis, possibly one of the more difficult bacteria to use because of its slow growth and assignment to Biosafety Level-3 by the CDC and NIH. The principles illuminated here, however, are relevant to the execution of most bacteria high-throughput screens.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 22%
Student > Bachelor 1 11%
Student > Master 1 11%
Researcher 1 11%
Student > Postgraduate 1 11%
Other 0 0%
Unknown 3 33%
Readers by discipline Count As %
Immunology and Microbiology 2 22%
Biochemistry, Genetics and Molecular Biology 2 22%
Pharmacology, Toxicology and Pharmaceutical Science 1 11%
Unknown 4 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2016.
All research outputs
#13,983,915
of 22,877,793 outputs
Outputs from Methods in molecular biology
#3,939
of 13,132 outputs
Outputs of similar age
#199,677
of 393,703 outputs
Outputs of similar age from Methods in molecular biology
#386
of 1,471 outputs
Altmetric has tracked 22,877,793 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,132 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,703 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,471 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.