| Chapter title |
Design and Implementation of High-Throughput Screening Assays
|
|---|---|
| Chapter number | 1 |
| Book title |
High Throughput Screening
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3673-1_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3671-7, 978-1-4939-3673-1
|
| Authors |
David J. Powell, Robert P. Hertzberg, Ricardo Macarrόn, Powell, David J., Hertzberg, Robert P., Macarrόn, Ricardo |
| Abstract |
HTS remains at the core of the drug discovery process, and so it is critical to design and implement HTS assays in a comprehensive fashion involving scientists from the disciplines of biology, chemistry, engineering, and informatics. This requires careful consideration of many options and variables, starting with the choice of screening strategy and ending with the discovery of lead compounds. At every step in this process, there are decisions to be made that can greatly impact the outcome of the HTS effort, to the point of making it a success or a failure. Although specific guidelines should be established to ensure that the screening assay reaches an acceptable level of quality, many choices require pragmatism and the ability to compromise opposing forces. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 7% |
| Unknown | 14 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 27% |
| Student > Doctoral Student | 3 | 20% |
| Student > Ph. D. Student | 3 | 20% |
| Researcher | 1 | 7% |
| Professor > Associate Professor | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 3 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 33% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 20% |
| Agricultural and Biological Sciences | 2 | 13% |
| Environmental Science | 1 | 7% |
| Unknown | 4 | 27% |