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Mendeley readers
| Chapter title |
Screening for Inhibitors of Kinase Autophosphorylation
|
|---|---|
| Chapter number | 10 |
| Book title |
High Throughput Screening
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3673-1_10 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3671-7, 978-1-4939-3673-1
|
| Authors |
Bianca Heedmann, Martin Klumpp, Heedmann, Bianca, Klumpp, Martin |
| Abstract |
Autophosphorylation of kinases influences their conformational state and can also regulate enzymatic activity. Recently, this has become an area of interest for drug discovery. Using Alk2 as an example, we present two protocols - one based on phosphate-binding Alphascreen beads, the other on coupled luminescence measurements of ADP formation - that can be used to screen for inhibitors of autophosphorylation. |
Mendeley readers
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 1 | 50% |
| Other | 1 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Business, Management and Accounting | 1 | 50% |
| Unknown | 1 | 50% |