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Yeast Genetics

Overview of attention for book
Cover of 'Yeast Genetics'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Yeast Transformation by the LiAc/SS Carrier DNA/PEG Method.
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    Chapter 2 Tetrad, random spore, and molecular analysis of meiotic segregation and recombination.
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    Chapter 3 PCR Mutagenesis and Gap Repair in Yeast
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    Chapter 4 PCR-Mediated Epitope Tagging of Genes in Yeast.
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    Chapter 5 Manipulating the yeast genome: deletion, mutation, and tagging by PCR.
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    Chapter 6 Preparation of yeast cells for live-cell imaging and indirect immunofluorescence.
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    Chapter 7 Single yeast cell imaging.
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    Chapter 8 Microfluidic platforms for generating dynamic environmental perturbations to study the responses of single yeast cells.
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    Chapter 9 Using Two-Hybrid Interactions to Identify Separation-of-Function Mutations.
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    Chapter 10 Synthetic Genetic Array Analysis for Global Mapping of Genetic Networks in Yeast
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    Chapter 11 Chemical genetic and chemogenomic analysis in yeast.
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    Chapter 12 Phenomic assessment of genetic buffering by kinetic analysis of cell arrays.
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    Chapter 13 Detection of Short-Range Chromatin Interactions by Chromosome Conformation Capture (3C) in Yeast.
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    Chapter 14 Chromosome Conformation Capture (3C) of Tandem Arrays in Yeast.
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    Chapter 15 Global Analysis of Transcription Factor-Binding Sites in Yeast Using ChIP-Seq.
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    Chapter 16 High-density tiling microarray analysis of the full transcriptional activity of yeast.
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    Chapter 17 Analysis of Silencing in Saccharomyces cerevisiae.
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    Chapter 18 A User's Guide to the Ribosomal DNA in Saccharomyces cerevisiae.
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    Chapter 19 Two-dimensional agarose gel electrophoresis for analysis of DNA replication.
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    Chapter 20 Replicative life span analysis in budding yeast.
  22. Altmetric Badge
    Chapter 21 Metabolomic and lipidomic analyses of chronologically aging yeast.
Attention for Chapter 11: Chemical genetic and chemogenomic analysis in yeast.
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  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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Chapter title
Chemical genetic and chemogenomic analysis in yeast.
Chapter number 11
Book title
Yeast Genetics
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-4939-1363-3_11
Pubmed ID
25213245
Book ISBNs
978-1-4939-1362-6, 978-1-4939-1363-3
Authors

Namal V C Coorey, Liam D P Sampson, Jacqueline M Barber, David S Bellows, Namal V. C. Coorey, Liam D. P. Sampson, Jacqueline M. Barber, David S. Bellows, Coorey, Namal V. C., Sampson, Liam D. P., Barber, Jacqueline M., Bellows, David S.

Abstract

Chemogenomics is the systematic genome-wide study of the cellular response to small molecule agents. Modern high-throughput genetic techniques allow massively parallel examination of the genetic effects of such biologically active small molecules (BASM). Here we present methodology for the identification and characterization of potentially bioactive compounds using the budding yeast Saccharomyces cerevisiae as a model organism. First, we present a method for screening libraries of compounds for growth inhibition in solid or liquid phase, followed by techniques for potency determination using a half-log dose response. Then the Deletion Mutant Array (DMA), a genome-wide library of single gene deletion strains, is used to probe the chemical genetic interactions of individual BASMs on genetic networks-a process that can be achieved with a solid phase pinning assay or a pooled liquid assay utilizing barcode microarray techniques. Finally, we offer some considerations for optimizing these protocols.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 46%
Student > Ph. D. Student 4 31%
Student > Master 2 15%
Unknown 1 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 38%
Agricultural and Biological Sciences 5 38%
Nursing and Health Professions 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Unknown 1 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2015.
All research outputs
#14,680,831
of 23,498,099 outputs
Outputs from Methods in molecular biology
#4,353
of 13,368 outputs
Outputs of similar age
#177,541
of 308,917 outputs
Outputs of similar age from Methods in molecular biology
#171
of 587 outputs
Altmetric has tracked 23,498,099 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,368 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,917 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 587 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.

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