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Chapter title |
Geno- and Phenotyping of Human Neutrophil Antigens
|
---|---|
Chapter number | 16 |
Book title |
Molecular Typing of Blood Cell Antigens
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Published in |
Methods in molecular biology, January 2015
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DOI | 10.1007/978-1-4939-2690-9_16 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2689-3, 978-1-4939-2690-9
|
Authors |
Angelika Reil, Jürgen Bux |
Abstract |
For typing of human neutrophil antigens (HNA) usually genotyping techniques are used, except for HNA-2, which-due to a gene expression defect-requires phenotyping. For genotyping, several techniques have been described. Most reference laboratories use variations of the polymerase chain reaction (PCR) for antigen typing which showed good results in international quality assessment exercises. The granulocyte immunofluorescence test has been the gold standard technique for phenotyping for all HNA antigens except for HNA-3a and -3b phenotyping. The expression of the latter antigens on neutrophils is often better shown by the use of the granulocyte agglutination test. |
Mendeley readers
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 1 | 50% |
Unknown | 1 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 50% |
Unknown | 1 | 50% |