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Cancer Epigenetics

Overview of attention for book
Cover of 'Cancer Epigenetics'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Epigenetic Markers of Early Tumor Development
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    Chapter 2 Epigenetics of Solid Cancer Stem Cells
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    Chapter 3 DNA Methylation and Histone Modifications in Breast Cancer
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    Chapter 4 DNA Methylation Changes in Prostate Cancer
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    Chapter 5 DNA methylation in promoter region as biomarkers in prostate cancer.
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    Chapter 6 Epigenetics of Bladder Cancer
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    Chapter 7 Epigenetics in Myeloid Malignancies
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    Chapter 8 The Epigenetics of Brain Tumors
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    Chapter 9 DNA Methylation Changes in Cervical Cancers
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    Chapter 10 Epigenetics of colon cancer.
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    Chapter 11 Promoter Methylation in Head and Neck Tumorigenesis
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    Chapter 12 Epigenome and DNA Methylation in Oral Squamous Cell Carcinoma
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    Chapter 13 Clinical Implications of Epigenetic Alterations in Human Thoracic Malignancies: Epigenetic Alterations in Lung Cancer
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    Chapter 14 The Role of MicroRNAs in the Management of Liver Cancer.
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    Chapter 15 Epigenetics in ovarian cancer.
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    Chapter 16 DNA Methylation in Pancreatic Cancer: Protocols for the Isolation of DNA and Bisulfite Modification
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    Chapter 17 Detection and analysis of DNA methylation by pyrosequencing.
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    Chapter 18 Screening for miRNA Expression Changes Using Quantitative PCR (Q-PCR).
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    Chapter 19 Genome-Wide Methylation Analysis
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    Chapter 20 Microarray for Epigenetic Changes: Gene Expression Arrays
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    Chapter 21 Detecting DNA Methylation Using the Methylated CpG Island Amplification and Microarray Technique
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    Chapter 22 Nutrigenomics: implications for breast and colon cancer prevention.
  24. Altmetric Badge
    Chapter 23 Dietary and lifestyle factors of DNA methylation.
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    Chapter 24 Diet, epigenetics, and cancer.
  26. Altmetric Badge
    Chapter 25 Role of Epigenetics in Cancer Health Disparities
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    Chapter 26 Multifactorial Etiology of Gastric Cancer
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    Chapter 27 Epigenetic Epidemiology for Cancer Risk: Harnessing Germline Epigenetic Variation
  29. Altmetric Badge
    Chapter 28 Epigenetic Biomarkers in Cancer Epidemiology
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    Chapter 29 Screening for miRNA Expression Changes Using Quantitative PCR (Q-PCR)
Attention for Chapter 10: Epigenetics of colon cancer.
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

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2 tweeters

Citations

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8 Dimensions

Readers on

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41 Mendeley
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1 CiteULike
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Chapter title
Epigenetics of colon cancer.
Chapter number 10
Book title
Cancer Epigenetics
Published in
Methods in molecular biology, February 2012
DOI 10.1007/978-1-61779-612-8_10
Pubmed ID
Book ISBNs
978-1-61779-611-1, 978-1-61779-612-8
Authors

Khare S, Verma M, Sharad Khare, Mukesh Verma, Khare, Sharad, Verma, Mukesh

Abstract

Accumulation of genetic and epigenetic alterations transforms normal colonic epithelial cells to adenocarcinoma cells. Genetic alterations include mutations in tumor suppressor genes and oncogenes, whereas epigenetic mechanisms are defined as heritable alterations in gene expression that is independent of changes in the primary DNA sequence. Role of epigenetic mechanisms in development and maintenance of organ- and tissue-specific gene expression is now realized. Disturbances in epigenetic landscape can lead to malignant cellular makeover, and these heritable changes are maintained through various cycles of cell division that renders cells to have discrete identity with similar genetic information. Epigenetic alterations in colorectal cancer (CRC) that transform colonic epithelial cells into adenocarcinoma cells include aberrant DNA methylation, chromatin modifications, and noncoding RNAs, especially microRNA expression. CpG island DNA methylation and aberrant methylation of genes drive the initiation and progression of CRC. Histone modifications impinge on chromatin structure and gene expression and thus play an important role in gene silencing in CRC. DNA hypermethylation also leads to downregulation and inappropriate expression of certain microRNAs that act like tumor suppressor genes. Determining the causes and roles of epigenetic instability in CRC pathogenesis will lead to effective prevention and therapeutic strategies for patients with CRC. Epigenetic drugs that underscore the reversible nature of epigenetic events have led the possibility of epigenetic therapy as a treatment option in CRC.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Denmark 1 2%
Germany 1 2%
Unknown 38 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 15%
Student > Ph. D. Student 5 12%
Student > Doctoral Student 5 12%
Student > Bachelor 4 10%
Student > Master 4 10%
Other 7 17%
Unknown 10 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 27%
Agricultural and Biological Sciences 8 20%
Medicine and Dentistry 5 12%
Nursing and Health Professions 2 5%
Immunology and Microbiology 2 5%
Other 3 7%
Unknown 10 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2012.
All research outputs
#11,236,117
of 17,359,532 outputs
Outputs from Methods in molecular biology
#3,468
of 9,915 outputs
Outputs of similar age
#78,120
of 129,997 outputs
Outputs of similar age from Methods in molecular biology
#15
of 52 outputs
Altmetric has tracked 17,359,532 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,915 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 129,997 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.