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Cancer Epigenetics

Overview of attention for book
Cover of 'Cancer Epigenetics'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Epigenetic Markers of Early Tumor Development
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    Chapter 2 Epigenetics of Solid Cancer Stem Cells
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    Chapter 3 DNA Methylation and Histone Modifications in Breast Cancer
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    Chapter 4 DNA Methylation Changes in Prostate Cancer
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    Chapter 5 DNA methylation in promoter region as biomarkers in prostate cancer.
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    Chapter 6 Epigenetics of Bladder Cancer
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    Chapter 7 Epigenetics in Myeloid Malignancies
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    Chapter 8 The Epigenetics of Brain Tumors
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    Chapter 9 DNA Methylation Changes in Cervical Cancers
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    Chapter 10 Epigenetics of colon cancer.
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    Chapter 11 Promoter Methylation in Head and Neck Tumorigenesis
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    Chapter 12 Epigenome and DNA Methylation in Oral Squamous Cell Carcinoma
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    Chapter 13 Clinical Implications of Epigenetic Alterations in Human Thoracic Malignancies: Epigenetic Alterations in Lung Cancer
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    Chapter 14 The Role of MicroRNAs in the Management of Liver Cancer.
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    Chapter 15 Epigenetics in ovarian cancer.
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    Chapter 16 DNA Methylation in Pancreatic Cancer: Protocols for the Isolation of DNA and Bisulfite Modification
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    Chapter 17 Detection and analysis of DNA methylation by pyrosequencing.
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    Chapter 18 Screening for miRNA Expression Changes Using Quantitative PCR (Q-PCR).
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    Chapter 19 Genome-Wide Methylation Analysis
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    Chapter 20 Microarray for Epigenetic Changes: Gene Expression Arrays
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    Chapter 21 Detecting DNA Methylation Using the Methylated CpG Island Amplification and Microarray Technique
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    Chapter 22 Nutrigenomics: implications for breast and colon cancer prevention.
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    Chapter 23 Dietary and lifestyle factors of DNA methylation.
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    Chapter 24 Diet, epigenetics, and cancer.
  26. Altmetric Badge
    Chapter 25 Role of Epigenetics in Cancer Health Disparities
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    Chapter 26 Multifactorial Etiology of Gastric Cancer
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    Chapter 27 Epigenetic Epidemiology for Cancer Risk: Harnessing Germline Epigenetic Variation
  29. Altmetric Badge
    Chapter 28 Epigenetic Biomarkers in Cancer Epidemiology
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    Chapter 29 Screening for miRNA Expression Changes Using Quantitative PCR (Q-PCR)
Attention for Chapter 23: Dietary and lifestyle factors of DNA methylation.
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#25 of 12,757)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
9 news outlets
twitter
2 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

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8 Dimensions

Readers on

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153 Mendeley
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Chapter title
Dietary and lifestyle factors of DNA methylation.
Chapter number 23
Book title
Cancer Epigenetics
Published in
Methods in molecular biology, February 2012
DOI 10.1007/978-1-61779-612-8_23
Pubmed ID
Book ISBNs
978-1-61779-611-1, 978-1-61779-612-8
Authors

Lim U, Song MA, Lim, Unhee, Song, Min-Ae, Unhee Lim, Min-Ae Song

Abstract

Lifestyle factors, such as diet, smoking, physical activity, and body weight management, are known to constitute the majority of cancer causes. Epigenetics has been widely proposed as a main mechanism that mediates the reversible effects of dietary and lifestyle factors on carcinogenesis. This chapter reviews human studies on potential dietary and lifestyle determinants of DNA methylation. Apart from a few prospective investigations and interventions of limited size and duration, evidence mostly comes from cross-sectional observational studies and supports some associations. Studies to date suggest that certain dietary components may alter genomic and gene-specific DNA methylation levels in systemic and target tissues, affecting genomic stability and transcription of tumor suppressors and oncogenes. Most data and supportive evidence exist for folate, a key nutritional factor in one-carbon metabolism that supplies the methyl units for DNA methylation. Other candidate bioactive food components include alcohol and other key nutritional factors of one-carbon metabolism, polyphenols and flavonoids in green tea, phytoestrogen, and lycopene. Some data also support a link of DNA methylation with physical activity and energy balance. Effects of dietary and lifestyle exposures on DNA methylation may be additionally modified by common genetic variants, environmental carcinogens, and infectious agents, an aspect that remains largely unexplored. In addition, growing literature supports that the environmental conditions during critical developmental stages may influence later risk of metabolic disorders in part through persistent programming of DNA methylation. Further research of these modifiable determinants of DNA methylation will improve our understanding of cancer etiology and may present certain DNA methylation markers as attractive surrogate endpoints for prevention research. Considering the plasticity of epigenetic marks and correlated nature of lifestyle factors, more longitudinal studies of healthy individuals of varying age, sex, and ethnic groups are warranted, ideally with comprehensive data collection on various lifestyle factors.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 <1%
Switzerland 1 <1%
Unknown 151 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 26%
Researcher 20 13%
Student > Master 20 13%
Student > Bachelor 18 12%
Professor 6 4%
Other 31 20%
Unknown 18 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 21%
Agricultural and Biological Sciences 31 20%
Medicine and Dentistry 23 15%
Nursing and Health Professions 13 8%
Neuroscience 6 4%
Other 24 16%
Unknown 24 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 74. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2022.
All research outputs
#466,756
of 22,214,042 outputs
Outputs from Methods in molecular biology
#25
of 12,757 outputs
Outputs of similar age
#3,787
of 180,460 outputs
Outputs of similar age from Methods in molecular biology
#1
of 42 outputs
Altmetric has tracked 22,214,042 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,757 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,460 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.