@realsci_DE Expression ≠ Funktion. Wildtyp-p53 ist normalerweise sehr gering exprimiert und daher per IHC nur schwer detektierbar. Mutationen, insbesondere in der DNA-Bindungsdomäne, führen zur Stabilisierung und Akkumulation im Kern. https://t.co/i3v8y6z4
$CRSP $NTLA $EDIT $SGMO $CLLS $QURE $ONCE $BMRN $RGNX https://t.co/uSuama38cK
With a quick search I found this (free) paper discussing p53's role in the repair mechanisms https://t.co/x3XYc3QLz0 and a role in inhibiting NHEJ has not been refuted. So what am I misunderstanding that @sxbegle has correct, or does she have it wrong?
Cancer Therapy News: Targeting p53-MDM2-MDMX Loop for Cancer Therapy.: Authors: Zhang Q, Zeng SX, Lu H Abs... http://t.co/TubyO26pgF