Mutant p53 and MDM2 in Cancer
Springer Netherlands
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Mendeley readers
Attention Score in Context
| Chapter title |
p53: Its Mutations and Their Impact on Transcription.
|
|---|---|
| Chapter number | 4 |
| Book title |
Mutant p53 and MDM2 in Cancer
|
| Published in |
Sub cellular biochemistry, September 2014
|
| DOI | 10.1007/978-94-017-9211-0_4 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-179210-3, 978-9-40-179211-0
|
| Authors |
Vaughan C, Pearsall I, Yeudall A, Deb SP, Deb S, Catherine Vaughan, Isabella Pearsall, Andrew Yeudall, Swati Palit Deb, Sumitra Deb, Vaughan, Catherine, Pearsall, Isabella, Yeudall, Andrew, Deb, Swati Palit, Deb, Sumitra |
| Abstract |
p53 is a tumor suppressor protein whose key function is to maintain the integrity of the cell. Mutations in p53 have been found in up to 50 % of all human cancers and cause an increase in oncogenic phenotypes such as proliferation and tumorigenicity. Both wild-type and mutant p53 have been shown to transactivate their target genes, either through directly binding to DNA, or indirectly through protein-protein interactions. This review discusses possible mechanisms behind both wild-type and mutant p53-mediated transactivation and touches on the concept of addiction to mutant p53 of cancer cells and how that may be used for future therapies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 14% |
| Student > Bachelor | 3 | 11% |
| Researcher | 3 | 11% |
| Student > Ph. D. Student | 3 | 11% |
| Student > Doctoral Student | 1 | 4% |
| Other | 4 | 14% |
| Unknown | 10 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 36% |
| Agricultural and Biological Sciences | 5 | 18% |
| Medicine and Dentistry | 2 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Unknown | 10 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2023.
All research outputs
#3,182,792
of 24,493,053 outputs
Outputs from Sub cellular biochemistry
#49
of 376 outputs
Outputs of similar age
#32,804
of 243,824 outputs
Outputs of similar age from Sub cellular biochemistry
#1
of 5 outputs
Altmetric has tracked 24,493,053 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 376 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,824 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them