Mutant p53 and MDM2 in Cancer
Springer Netherlands
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Mendeley readers
| Chapter title |
p53 Mutation in the Genesis of Metastasis.
|
|---|---|
| Chapter number | 6 |
| Book title |
Mutant p53 and MDM2 in Cancer
|
| Published in |
Sub cellular biochemistry, September 2014
|
| DOI | 10.1007/978-94-017-9211-0_6 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-179210-3, 978-9-40-179211-0
|
| Authors |
Yeudall WA, W. A. Yeudall, Yeudall, W. A. |
| Abstract |
Development of metastatic cancer is a complex series of events that includes genesis of tumor-related vascular and lymphatic systems, enhanced cellular motility, and the capacity to invade and survive at distant sites, as well as evasion of host defences. The wild-type p53 protein plays key roles in controlling these facets of tumor progression, and loss of normal p53 function can be sufficient to predispose tumor cells to gain metastatic properties. In contrast, dominant p53 mutants that have gained oncogenic functions can actively drive metastasis through a variety of mechanisms. This chapter aims to highlight these processes. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 13% |
| Unknown | 7 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 38% |
| Student > Bachelor | 1 | 13% |
| Professor | 1 | 13% |
| Student > Master | 1 | 13% |
| Researcher | 1 | 13% |
| Other | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 50% |
| Medicine and Dentistry | 2 | 25% |
| Immunology and Microbiology | 1 | 13% |
| Biochemistry, Genetics and Molecular Biology | 1 | 13% |