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Mutant p53 and MDM2 in Cancer

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Cover of 'Mutant p53 and MDM2 in Cancer'

Table of Contents

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    Book Overview
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    Chapter 1 p53 and Hereditary Cancer
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    Chapter 2 Alterations of p63 and p73 in Human Cancers.
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    Chapter 3 Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
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    Chapter 4 p53: Its Mutations and Their Impact on Transcription.
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    Chapter 5 Transcriptional Regulation by Mutant p53 and Oncogenesis
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    Chapter 6 p53 Mutation in the Genesis of Metastasis.
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    Chapter 7 Structural Studies on Mechanisms to Activate Mutant p53
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    Chapter 8 Mutant p53 and the Response to Chemotherapy and Radiation
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    Chapter 9 Mutant p53 and MDM2 in Cancer
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    Chapter 10 Mechanisms of Mutant p53 Stabilization in Cancer
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    Chapter 11 Crosstalk Between Mdm2, p53 and HIF1-α: Distinct Responses to Oxygen Stress and Implications for Tumour Hypoxia.
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    Chapter 12 MDM2 Overexpression, Activation of Signaling Networks, and Cell Proliferation
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    Chapter 13 p53-Independent Effects of Mdm2
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    Chapter 14 Splice Variants of MDM2 in Oncogenesis.
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    Chapter 15 Mdm2 and MdmX Involvement in Human Cancer.
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    Chapter 16 Targeting p53-MDM2-MDMX Loop for Cancer Therapy.
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    Chapter 17 Involvement of p53 in the Repair of DNA Double Strand Breaks: Multifaceted Roles of p53 in Homologous Recombination Repair (HRR) and Non-Homologous End Joining (NHEJ).
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    Chapter 18 The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism.
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    Chapter 19 Lung Cancer Stem Cells, p53 Mutations and MDM2
Attention for Chapter 6: p53 Mutation in the Genesis of Metastasis.
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Chapter title
p53 Mutation in the Genesis of Metastasis.
Chapter number 6
Book title
Mutant p53 and MDM2 in Cancer
Published in
Sub cellular biochemistry, September 2014
DOI 10.1007/978-94-017-9211-0_6
Pubmed ID
Book ISBNs
978-9-40-179210-3, 978-9-40-179211-0
Authors

Yeudall WA, W. A. Yeudall, Yeudall, W. A.

Abstract

Development of metastatic cancer is a complex series of events that includes genesis of tumor-related vascular and lymphatic systems, enhanced cellular motility, and the capacity to invade and survive at distant sites, as well as evasion of host defences. The wild-type p53 protein plays key roles in controlling these facets of tumor progression, and loss of normal p53 function can be sufficient to predispose tumor cells to gain metastatic properties. In contrast, dominant p53 mutants that have gained oncogenic functions can actively drive metastasis through a variety of mechanisms. This chapter aims to highlight these processes.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 13%
Unknown 7 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 38%
Student > Bachelor 1 13%
Professor 1 13%
Student > Master 1 13%
Researcher 1 13%
Other 1 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 50%
Medicine and Dentistry 2 25%
Immunology and Microbiology 1 13%
Biochemistry, Genetics and Molecular Biology 1 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2014.
All research outputs
#20,247,117
of 22,775,504 outputs
Outputs from Sub cellular biochemistry
#295
of 354 outputs
Outputs of similar age
#200,239
of 238,983 outputs
Outputs of similar age from Sub cellular biochemistry
#3
of 5 outputs
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So far Altmetric has tracked 354 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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