Mutant p53 and MDM2 in Cancer

Chapter 1 p53 and Hereditary Cancer

Chapter 2 Alterations of p63 and p73 in Human Cancers.

Chapter 3 Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer

Chapter 4 p53: Its Mutations and Their Impact on Transcription.

Chapter 5 Transcriptional Regulation by Mutant p53 and Oncogenesis

Chapter 6 p53 Mutation in the Genesis of Metastasis.

Chapter 7 Structural Studies on Mechanisms to Activate Mutant p53

Chapter 8 Mutant p53 and the Response to Chemotherapy and Radiation

Chapter 9 Mutant p53 and MDM2 in Cancer

Chapter 10 Mechanisms of Mutant p53 Stabilization in Cancer

Chapter 11 Crosstalk Between Mdm2, p53 and HIF1-α: Distinct Responses to Oxygen Stress and Implications for Tumour Hypoxia.

Chapter 12 MDM2 Overexpression, Activation of Signaling Networks, and Cell Proliferation

Chapter 13 p53-Independent Effects of Mdm2

Chapter 14 Splice Variants of MDM2 in Oncogenesis.

Chapter 15 Mdm2 and MdmX Involvement in Human Cancer.

Chapter 16 Targeting p53-MDM2-MDMX Loop for Cancer Therapy.

Chapter 17 Involvement of p53 in the Repair of DNA Double Strand Breaks: Multifaceted Roles of p53 in Homologous Recombination Repair (HRR) and Non-Homologous End Joining (NHEJ).

Chapter 18 The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism.

Chapter 19 Lung Cancer Stem Cells, p53 Mutations and MDM2