Chapter title |
Protein-Protein Interaction Databases
|
---|---|
Chapter number | 3 |
Book title |
Protein-Protein Interactions
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2425-7_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2424-0, 978-1-4939-2425-7
|
Authors |
Damian Szklarczyk, Lars Juhl Jensen, Szklarczyk, Damian, Jensen, Lars Juhl |
Abstract |
Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored. Here we present an overview of the most widely used protein-protein interaction databases and the methods they employ to gather, combine, and predict interactions. We also point out the trade-off between comprehensiveness and accuracy and the main pitfall scientists have to be aware before adopting protein interaction databases in any single-gene or genome-wide analysis. |
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Demographic breakdown
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Student > Master | 5 | 16% |
Researcher | 5 | 16% |
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Student > Doctoral Student | 2 | 6% |
Other | 2 | 6% |
Unknown | 7 | 22% |
Readers by discipline | Count | As % |
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Earth and Planetary Sciences | 1 | 3% |
Other | 3 | 9% |
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